Dungeons & Dragons doesn't have a lot to say about Alchemy beyond letting you craft certain potions of a magical nature. Pathfinder is barely better, with it's weird Alchemist class. This isn't really the fault of RPGs, though.
It's hard to sort through the historical record and find anything that provides a concrete theme specific enough to latch onto. But never fear, we've concocted an episode from the available ingredients and distilled them down into the the history of alchemy and how we got from there, to here.
You can support us on Patreon.